Relevant Links
Curriculum Vitae
EDUCATION
2012-2016
Ph.D., Medicine
Kolling Institute, University of Sydney, NSW, Australia
2006-2010
B.Sc.(Adv)(Hons I), Pharmacology/Chemistry
University of Sydney, NSW, Australia
RESEARCH EXPERIENCE
2018-present
Postdoctoral Fellow
Department of Genetics, Harvard Medical School, Boston, MA, USA
Supervisor: Dr David Sinclair
2016-2017
Postdoctoral Fellow
Department of Pharmacology, Dalhousie University, Halifax, NS, Canada
Supervisor: Dr Susan Howlett
2012-2016
Graduate Student
Kolling Institute, University of Sydney, NSW, Australia
Supervisors: Dr Sarah Hilmer, Dr David Le Couteur and Dr Victoria Cogger
Thesis Title: Paracetamol Toxicity: Influence of Ageing, Frailty, Resveratrol and SIRT1
2013-2014
Visiting Student
Translational Gerontology Branch, NIA, Baltimore, MD, USA
Supervisor: Dr Rafael de Cabo
2011, 2016
Research Assistant
Department of Clinical Pharmacology and Ageing, Kolling Institute
University of Sydney, NSW, Australia
Supervisor: Dr Sarah Hilmer
2010
Undergraduate honours student
Kolling Institute, University of Sydney, NSW, Australia
Supervisors: Dr Sarah Hilmer, Dr Peter Carroll and Dr Slade Matthews
SELECTED PRESENTATIONS
Kane AE, Schultz MB, Mitchell SJ, MacArthur MR, Warner E, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. Cold Spring Harbor Laboratory Mechanisms of Aging (Virtual). Sept 22nd-25th 2020.
Kane AE, Schultz MB, Mitchell SJ, MacArthur MR, Warner E, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. 7th Aging Research and Drug Discovery Meeting (Virtual). Sept 1-4th 2020.
Kane AE, Schultz MB, Mitchell SJ, MacArthur MR, Warner E, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. The Jackson Laboratory Systems Immunology in Aging and Complex Diseases (Virtual). Sept 2-3rd 2020.
Kane AE, Schultz MB, Mitchell SJ, MacArthur MR, Warner E, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. AGE Virtual Meeting. June 19th 2020.
Kane AE, Schultz MB, Mitchell SJ, MacArthur MR, Warner E, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. Aging in Isolation Online Seminar Series. May 12th 2020.
Kane AE, Schultz MB, Mitchell SJ, MacArthur MR, Warner E, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. Brigham Aging and Cardiometabolic Health Symposium. Boston, USA, Dec 3rd 2019.
Kane AE, Schultz MB, Mitchell SJ, MacArthur MR, Warner E, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. RCCN Workshop: Resilience and Reserve in Aging. Austin, USA, Nov 12th 2019.
Kane A, Keller K, Feridooni H, Heinze-Milne S, Grandy SA & Howlett SE. Chronic treatment with the ACE inhibitor enalapril attenuates the development of frailty, prevents cardiac hypertrophy and increases IL-10 levels in aging male C57BL/6 mice. International Society for Heart Research (ISHR) North American Section Annual Meeting. Halifax, NS, 29th May – 1st June 2018.
Kane AE, Gregson E, Theou O, Rockwood K & Howlett SE. The Association Between Frailty Index and the Metabolic Syndrome Over the Lifespan. 21st IAGG World Congress of Gerontology and Geriatrics. San Francisco, USA, 23rd- 27th July 2017.
Kane A, Keller K, & Howlett SE. Influence of ACE inhibitors on frailty and cardiac function in middle-aged female C57BL/6 mice. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. Melbourne, Australia, 27th Nov-30th Nov 2016.
Kane A, Gregson E, Theou O, Rockwood K & Howlett SE. Frailty, the metabolic syndrome and mortality over the lifespan. Dalhousie University Cardiac Research Day. Halifax, Canada, 3rd Oct 2016.
Kane A, Keller K, & Howlett SE. Influence of ACE inhibitors on frailty and cardiac function in middle-aged female C57BL/6 mice. 4th Annual Meeting of the International Academy of Cardiovascular Sciences. Award Session, Sherbrooke Canada, 22nd-24th Sept 2016.
Kane A, Mitchell SJ, Mach J, Huizer-Pajkos A, McKenzie C, Jones B, Cogger V, le Couteur D, de Cabo R & Hilmer SN. Paracetamol hepatotoxicity in mice: Effect of age, frailty, N-acetyl cysteine and exposure type. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. Award Session, Hobart, Australia, 29th Nov-2nd Dec 2015.
Kane A, Mitchell SJ, Huizer-Pajkos A, Mach J, Cogger V, le Couteur D, de Cabo R & Hilmer SN. Resveratrol and SIRT1 do not protect against paracetamol toxicity. 44th Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. Melbourne, Australia, 7th-11th Dec 2014.
Kane A, Mitchell SJ, de Cabo R, Howlett SE & Hilmer SN. A Validated Mouse Frailty Index: Impact of Factors That Affect Lifespan. 13th National Conference of Emerging Researchers in Ageing. Adelaide, Australia, 24th-25th November 2014.
FELLOWSHIPS AND GRANTS
Postdoctoral
2020-2021 Irene Diamond Postdoctoral Transition Award, American Federation of Aging Research
2019-2020 University of Washington Nathan Shock Pilot Grant
2018-2019 CJ Martin Early Career Fellowship, National Health and Medical Research Council Australia
2016-2017 Reynolds Postdoctoral Fellowship, Dalhousie University
Graduate and Undergraduate
2012-2015 Postgraduate Biomedical Scholarship, National Health and Medical Research Council
2012-2015 Postgraduate Top-Up Scholarship, Northern Clinical School, University of Sydney
2012 Australian Association of Gerontology RM Gibson Scientific Research Grant, $8107
2006-2008 Sydney University Science Alumni Scholarship
HONORS AND AWARDS
Postdoctoral
2020 JAX Systems Immunology in Aging and Complex Diseases 2nd Place Oral Presentation
2020 AGE Virtual Meeting Oral Presentation Finalist
2019 RCCN workshop ‘Resilience and Reserve in Aging’ Travel Award
2019 Brigham Aging and Cardiometabolic Health Symposium Oral Presentation Award
2018 National Institute on Aging (NIA) Butler-Williams Scholar
2018 International Society of Heart Research, North American Section, Travel Award
2018 Summer Training Course on the Biology of Aging Scholar, Buck Institute
2017 International Society of Heart Research, North American Section, Travel Award
2016-2017 Cardiovascular Research Group, Dalhousie University, Travel Award
2016 Finalist in IACS James Willerson Young Investigator Award Competition
2016 Faculty of Graduate Studies, Dalhousie University, Travel Award
Graduate
2015 Finalist in ASCEPT Garth McQueen Oral Prize Session
2014 Emerging Researchers in Ageing Conference, Best Oral Presentation Award
2014 Australian Society of Clinical and Experimental Pharmacologists Conference Travel Award
2014 Australian Society of Clinical and Experimental Pharmacologists IUPHAR Travel Grant
2013 Beryl and Jack Jacobs International Travel Award
2013 Sydney Medical School Travelling Fellowship
2013 Royal North Shore Hospital Scientific Staff Council Study Fellowship
2013 Runner-up, Northern Clinical School 3 Minute Thesis Competition
2012-2014 Postgraduate Research Student Support Scheme (PRSS) Training Funding
2012 Australian Society of Clinical and Experimental Pharmacologists Travel Bursary
INVITED PRESENTATIONS
2020 “Age and life expectancy clocks based on machine learning analysis of mouse frailty”, HMS Genetics department seminar series, May 1st 2020
2019 “Why Harvard Medical School Is The Leader In Aging Reversal Research”, Harvard 1969 50th Reunion, 28th May
2017 Panelist, “Choosing a postdoc lab”, International Society of Heart Research, North American Section Annual Meeting, 30th May 2017
2016 “Preclinical studies of frailty using a mouse clinical frailty index”, Dalhousie Geriatric Academic Rounds, 14th December 2016 (Feedback score of 4.8/5.0)
2016 “Preclinical Studies of Frailty: Acetaminophen Toxicity, Polypharmacy and Longevity Interventions”, Dalhousie Pharmacology Department Seminar Series, 13th September 2016
2015 “What makes a supervisor good or bad? – A Student Perspective”, Kolling Institute Research Seminar, 26th August
2012-2015 Royal North Shore Hospital Aged Care Departmental Meetings
SERVICE AND LEADERSHIP
Committees
2020 Co-chair, Diversity, equity, inclusion, and outreach committee, American Aging Association
2016-2017 Co-President of the Dalhousie University Postdoctoral Society
2016-2017 Board Member, Dalhousie University Club
2014-2015 Member, Student and Early Career Committee, Australian Association of Gerontology
2013 Member, Executive Committee of the Scientific Staff Council, Northern Clinical School, University of Sydney
2013 Postgraduate Research Student Society President, Northern Clinical School, University of Sydney
2012-2015 Member, Postgraduate Research Student Society Executive, Northern Clinical School, University of Sydney
Peer Review
2020-present Scientific Reports
2019-present AJP-Heart and Circulatory Physiology
2019-present Aging
2018-present Mechanisms of Aging and Development
2016-present Journals of Gerontology: Biological Sciences
2016-present Clinical Interventions in Aging
Professional Societies
2019-present Member of the American Aging Association (AGE)
2018-present Member of the American Heart Association (AHA)
2017-2019 Member of the International Society of Heart Research (ISHR)
2013-present Member of the Gerontological Society of America (GSA)
2012-present Member of the Australian Association of Gerontology (AAG)
2010-present Member of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)
Other
2020 Facilitator of peer review job application document triangles for FuturePI Slack
2020 Sinclair lab COVID safety officer
2019 Co-guest editor special issue ‘Biology of Frailty’, Mechanisms of Aging and Development
2017 Judge, 3 Minute Thesis Competition, Dalhousie University
2017 Judge, Graduate Student Research Day, Dalhousie University
2016 Co-chair, Dalhousie University Postdoctoral Fellow Research Day
2013-2015 Northern Clinical School Volunteer for OSCE Medical School Exams
2012 Co-Chair, ‘Careers in the Pharmaceutical Industry’, 46th Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting